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Sodium valproate and valproic acid look to lower barbiturate metabolism; for that reason, barbiturate blood stages should be monitored and ideal dosage changes made as indicated.
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The concomitant usage of Liquor or other CNS depressants could develop additive CNS depressant consequences.
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Barbiturates may be behavior forming. Tolerance and psychological and physical dependence might occur with continuing use.
MAOI extend the results of barbiturates most likely for the reason that metabolism from the barbiturate is inhibited.